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Article

Inhibition of C5 or absence of C6 protects from sepsis mortality.

Immunobiology - 1 Jan 2004

Buras Jon A, Rice Lauren, Orlow Daniel, Pavlides Stavros, Reenstra Wende R, Ceonzo Kathleen, Stahl Gregory L

Abstract excerpt

Inhibiting complement anaphlytoxin C5a during sepsis may prevent sepsis mortality. Although human anti-C5 antibodies exist, their therapeutic use in microbial sepsis has been avoided because of the hypothesis that inhibiting C5b will prevent formation of the bactericidal membrane attack complex (MAC) and worsen clinical outcome. We wished to test the hypothesis that inhibition of C5 would improve outcomes in...

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Source

Identifiers

PMID: 15638131
DOI: 10.1016/j.imbio.2004.09.004

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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