Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expanding the Interactome of the Noncanonical NF-κB Signaling Pathway.

Journal of proteome research - 2 Sept 2016

Willmann Katharina L, Sacco Roberto, Martins Rui, Garncarz Wojciech, Krolo Ana, Knapp Sylvia, Bennett Keiryn L, Boztug Kaan

Abstract excerpt

NF-κB signaling is a central pathway of immunity and integrates signal transduction upon a wide array of inflammatory stimuli. Noncanonical NF-κB signaling is activated by a small subset of TNF family receptors and characterized by NF-κB2/p52 transcriptional activity. The medical relevance of this pathway has recently re-emerged from the discovery of primary immunodeficiency patients that have loss-of-function...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to I-kappa B Kinase
Share to Mass Spectrometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-kappa B

Share to Protein Binding

Share to Protein Interaction Maps

Share to Protein Serine-Threonine Kinases

Share to Signal Transduction

Share to Tacrolimus Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27416764
DOI: 10.1021/acs.jproteome.5b01004
PMCID: PMC5295629

Genes

FKBP8
TNF
TRAF2
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expanding the Interactome of the Noncanonical NF-κB Signaling Pathway.PMID 27416764Read ↗

Mendelian diseases of dysregulated canonical NF-κB signaling: From immunodeficiency to inflammation.Semantic proximity Read ↗

Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency.Semantic proximity Read ↗

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.Semantic proximity Read ↗

Rare mendelian primary immunodeficiency diseases associated with impaired NF-κB signaling.Semantic proximity Read ↗

Noncanonical NF-κB signaling is limited by classical NF-κB activity.Semantic proximity Read ↗

Non‐canonical NF‐κB signaling activation and regulation: principles and perspectivesSemantic proximity Read ↗

Targeting NF-κB-Inducing Kinase (NIK) in Immunity, Inflammation, and CancerSemantic proximity Read ↗

Integrated Multi-omics Analyses of NFKB1 patients B cells points towards an up regulation of NF-κB network inhibitorsSemantic proximity Read ↗

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.Semantic proximity Read ↗

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.Semantic proximity Read ↗

Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype.Semantic proximity Read ↗

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.