Article
Rare mendelian primary immunodeficiency diseases associated with impaired NF-κB signaling.
Genes and immunity - 1 Jun 2015
Paciolla M, Pescatore A, Conte M I, Esposito E, Incoronato M, Lioi M B, Fusco F, Ursini M V
Abstract excerpt
Mendelian primary immunodeficiency diseases (MPIDs) are rare disorders affecting distinct constituents of the innate and adaptive immune system. Although they are genetically heterogeneous, a substantial group of MPIDs is due to mutations in genes affecting the nuclear factor-κB (NF-κB) transcription pathway, essential for cell proliferation and cell survival and involved in innate immunity and inflammation. Many...
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