Article

Integrated Multi-omics Analyses of NFKB1 patients B cells points towards an up regulation of NF-κB network inhibitors

2022-11-23

Abstract excerpt

The transcription factor NF-κB plays a pivotal role in the adaptive immune response. Pathogenic variants in NFKB1 are the most common genetic etiology of common variable immunodeficiency (CVID). Patients frequently present with impaired terminal B cell differentiation, autoimmunity, and hyperinflammatory immune dysregulation. NF-κB signaling and target gene expression are expected to be dysregulated in NFKB1 -mu...

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Literature Corpus work: 1ca577bb-7e2a-527a-aa72-3b4ec6514de4
DOI: 10.1101/2022.11.22.517350

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