Article
Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway.
Biochemical and biophysical research communications - 14 Oct 2016
Song Haibo, Xu Jia, Lv Nan, Zhang Yuzhu, Wu Fei, Li Huanjie, Shao Lei, Mu Qian, Wang Fang, Tang Dongqi, Fang Xu
Abstract excerpt
Vascular smooth muscle cells (VSMCs) phenotype modulation toward a synthetic phenotype is the main cause of cardiovascular disease. As a newly discovered myokine, Irisin is thought to be a promising candidate for the treatment of metabolic disturbances, as well as cardiovascular disease. However, no evidence has been shown for the direct effect of Irisin on VSMCs phenotype modulation and its underling mechanisms....
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