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Article

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models.

BMC cancer - 14 Jul 2016

Phelan J P, Reen F J, Dunphy N, O'Connor R, O'Gara F

Abstract excerpt

BACKGROUND: The role of the microbiome has become synonymous with human health and disease. Bile acids, as essential components of the microbiome, have gained sustained credibility as potential modulators of cancer progression in several disease models. At physiological concentrations, bile acids appear to influence cancer phenotypes, although conflicting data surrounds their precise physiological mechanism of...

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Identifiers

PMID: 27416726
DOI: 10.1186/s12885-016-2528-2
PMCID: PMC4946243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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