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Article

Rare Variants in the ADAMTS13 Von Willebrand Factor-Binding Domain Contribute to Pediatric Stroke.

Circulation. Cardiovascular genetics - 1 Aug 2016

Stoll Monika, Rühle Frank, Witten Anika, Barysenka Andrei, Arning Astrid, Strauss Christina, Nowak-Göttl Ulrike

Abstract excerpt

BACKGROUND: Recently, we reported a gene network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) genes as central component of the genetic risk contributing to pediatric stroke. ADAMTS13 is a prime example for such a key component as it cleaves von Willebrand factor multimers, reduces platelet adhesion and aggregation, and downregulates thrombus formation and inflammation. METHODS...

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Source

Identifiers

PMID: 27412500
DOI: 10.1161/CIRCGENETICS.115.001184

Genes

ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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