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Article

Mutations and Common Polymorphisms in ADAMTS13 and vWF Genes Responsible for Increasing Risk of Thrombosis.

Cardiovascular & hematological disorders drug targets - 1 Jan 2018

Haybar Habib, Khodadi Elahe, Kavianpour Maria, Saki Najmaldin

Abstract excerpt

BACKGROUND AND OBJECTIVE: ADAMTS13 (A Disintegrin-like and Metalloproteases with Thrombospondin type-1 repeats, member-13) plays an important role in vascular hemostasis by cleaving the von Willebrand Factor (vWF). ADAMTS13 and vWF are involved in the development of ischemic heart disease. In this review paper, we examine the effects of Single Nucleotide Polymorphisms (SNPs) and mutations in the vWF and ADAMTS13...

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Source

Identifiers

PMID: 29669506
DOI: 10.2174/1871529X18666180419102214

Genes

ADAMTS13
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Mutations and Common Polymorphisms in ADAMTS13 and vWF Genes Responsible for Increasing Risk of Thrombosis.PMID 29669506Read ↗

[Genetic polymorphism of von Willebrand factor (VWF)-cleaving protease, ADAMTS13].Semantic proximity Read ↗

Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events.Semantic proximity Read ↗

SNPs in ADAMTS13.Semantic proximity Read ↗

Polymorphisms and mutations in vWF and ADAMTS13 genes and their correlation with plasma levels of FVIII and vWF in patients with deep venous thrombosis.Semantic proximity Read ↗

Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients.Semantic proximity Read ↗

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update.Semantic proximity Read ↗

Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.Semantic proximity Read ↗

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Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review.Semantic proximity Read ↗

High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability.Semantic proximity Read ↗

Next-generation sequencing study finds an excess of rare, coding single-nucleotide variants of ADAMTS13 in patients with deep vein thrombosis.Semantic proximity Read ↗

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