Article
Genetic variants in the ADAMTS13 and SUPT3H genes are associated with ADAMTS13 activity.
Blood - 18 Jun 2015
de Vries Paul S, Boender Johan, Sonneveld Michelle A H, Rivadeneira Fernando, Ikram M Arfan, Rottensteiner Hanspeter, Hofman Albert, Uitterlinden André G, Leebeek Frank W G, Franco Oscar H, Dehghan Abbas, de Maat Moniek P M
Abstract excerpt
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13) cleaves von Willebrand factor, reducing its prothrombotic activity. The genetic determinants of ADAMTS13 activity remain unclear. We performed a genome-wide association study of ADAMTS13 activity in the Rotterdam Study, a population-based cohort study. We used imputed genotypes of common variants in a discovery sample of 3443 individuals...
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