Article
Linear mixed model for heritability estimation that explicitly addresses environmental variation.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2016
Heckerman David, Gurdasani Deepti, Kadie Carl, Pomilla Cristina, Carstensen Tommy, Martin Hilary, Ekoru Kenneth, Nsubuga Rebecca N, Ssenyomo Gerald, Kamali Anatoli, Kaleebu Pontiano, Widmer Christian, Sandhu Manjinder S
Abstract excerpt
The linear mixed model (LMM) is now routinely used to estimate heritability. Unfortunately, as we demonstrate, LMM estimates of heritability can be inflated when using a standard model. To help reduce this inflation, we used a more general LMM with two random effects-one based on genomic variants and one based on easily measured spatial location as a proxy for environmental effects. We investigated this approach...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.