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Article

Fast and Accurate Construction of Confidence Intervals for Heritability.

American journal of human genetics - 2 Jun 2016

Schweiger Regev, Kaufman Shachar, Laaksonen Reijo, Kleber Marcus E, März Winfried, Eskin Eleazar, Rosset Saharon, Halperin Eran

Abstract excerpt

Estimation of heritability is fundamental in genetic studies. Recently, heritability estimation using linear mixed models (LMMs) has gained popularity because these estimates can be obtained from unrelated individuals collected in genome-wide association studies. Typically, heritability estimation under LMMs uses the restricted maximum likelihood (REML) approach. Existing methods for the construction of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27259052
DOI: 10.1016/j.ajhg.2016.04.016
PMCID: PMC4908190

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