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Article

Electrostatic effects on the folding stability of FKBP12.

Protein engineering, design & selection : PEDS - 1 Aug 2016

Batra Jyotica, Tjong Harianto, Zhou Huan-Xiang

Abstract excerpt

The roles of electrostatic interactions in protein folding stability have been a matter of debate, largely due to the complexity in the theoretical treatment of these interactions. We have developed computational methods for calculating electrostatic effects on protein folding stability. To rigorously test and further refine these methods, here we carried out experimental studies into electrostatic effects on the...

Topics

Amino Acid Substitution
Humans
Mutation
Protein Folding
Protein Stability
Protein Unfolding
Static Electricity
Tacrolimus Binding Protein 1A
Thermodynamics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27381026
DOI: 10.1093/protein/gzw014
PMCID: PMC4955870

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