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Article

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.

Human molecular genetics - 15 Aug 2016

Kang Silvia S, Kurti Aishe, Wojtas Aleksandra, Baker Kelsey E, Liu Chia-Chen, Kanekiyo Takahisa, Deming Yuetiva, Cruchaga Carlos, Estus Steven, Bu Guojun, Fryer John D

Abstract excerpt

Although abundant genetic and biochemical evidence strongly links Clusterin (CLU) to Alzheimer disease (AD) pathogenesis, the receptor for CLU within the adult brain is currently unknown. Using unbiased approaches, we identified Plexin A4 (PLXNA4) as a novel, high-affinity receptor for CLU in the adult brain. PLXNA4 protein expression was high in brain with much lower levels in peripheral organs. CLU protein...

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Identifiers

PMID: 27378688
DOI: 10.1093/hmg/ddw188
PMCID: PMC5179943

Genes

PLXNA4
CLU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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