Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer.

doi:10.1016/j.ebiom.2016.06.032

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Article

Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer.

EBioMedicine - 1 Aug 2016

Fernandez-Cuesta Lynnette, Perdomo Sandra, Avogbe Patrice H, Leblay Noemie, Delhomme Tiffany M, Gaborieau Valerie, Abedi-Ardekani Behnoush, Chanudet Estelle, Olivier Magali, Zaridze David, Mukeria Anush, Vilensky Marta, Holcatova Ivana, Polesel Jerry, Simonato Lorenzo, Canova Cristina, Lagiou Pagona, Brambilla Christian, Brambilla Elisabeth, Byrnes Graham, Scelo Ghislaine, Le Calvez-Kelm Florence, Foll Matthieu, McKay James D, Brennan Paul

Abstract excerpt

Circulating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis surveillance but it may also play a crucial role in the detection of pre-clinical cancer. Small-cell lung cancer (SCLC) is an excellent candidate for early detection given there are no successful therapeutic options for late-stage disease, and it displays almost universal inactivation of TP53. We assessed the presence of...

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Identifiers

PMID: 27377626
DOI: 10.1016/j.ebiom.2016.06.032
PMCID: PMC5036515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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