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Article

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

4 Sept 2023

Abstract excerpt

Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles. IL2RG is essential for the development, differentiation, and functioning of T, B, and NK cells, while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination...

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PMID: 37661226
DOI: 10.1038/s41392-023-01544-y

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