Article
Social disinhibition is a heritable subphenotype of tics in Tourette syndrome.
Neurology - 2 Aug 2016
Hirschtritt Matthew E, Darrow Sabrina M, Illmann Cornelia, Osiecki Lisa, Grados Marco, Sandor Paul, Dion Yves, King Robert A, Pauls David L, Budman Cathy L, Cath Danielle C, Greenberg Erica, Lyon Gholson J, Yu Dongmei, McGrath Lauren M, McMahon William M, Lee Paul C, Delucchi Kevin L, Scharf Jeremiah M, Mathews Carol A
Abstract excerpt
OBJECTIVE: To identify heritable symptom-based subtypes of Tourette syndrome (TS). METHODS: Forty-nine motor and phonic tics were examined in 3,494 individuals (1,191 TS probands and 2,303 first-degree relatives). Item-level exploratory factor and latent class analyses (LCA) were used to identify tic-based subtypes. Heritabilities of the subtypes were estimated, and associations with clinical characteristics were...
Topics
- Adolescent
- Adult
- Age of Onset
- Attention Deficit Disorder with Hyperactivity
- Canada
- Comorbidity
- Factor Analysis, Statistical
- Female
- Humans