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Article

Site-specific recombinatorics: in situ cellular barcoding with the Cre Lox system.

BMC systems biology - 30 Jun 2016

Weber Tom S, Dukes Mark, Miles Denise C, Glaser Stefan P, Naik Shalin H, Duffy Ken R

Abstract excerpt

BACKGROUND: Cellular barcoding is a recently developed biotechnology tool that enables the familial identification of progeny of individual cells in vivo. In immunology, it has been used to track the burst-sizes of multiple distinct responding T cells over several adaptive immune responses. In the study of hematopoiesis, it revealed fate heterogeneity amongst phenotypically identical multipotent cells. Most...

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PMID: 27363727
DOI: 10.1186/s12918-016-0290-3
PMCID: PMC4929723

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