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Article

von Willebrand factor propeptide: biology and clinical utility

27 Jul 2015

Abstract excerpt

von Willebrand factor (VWF) is a large multimeric glycoprotein that mediates the attachment of platelets to damaged endothelium and also serves as the carrier protein for coagulation factor VIII (FVIII), protecting it from proteolytic degradation. Quantitative or qualitative defects in VWF result in von Willebrand disease (VWD), a common inherited bleeding disorder. VWF is synthesized with a very large propeptide...

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PMID: 26215113
DOI: 10.1182/blood-2015-04-512731

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