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Article

Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle.

Cardiovascular research - 1 May 2018

Rech Monika, Barandiarán Aizpurua Arantxa, van Empel Vanessa, van Bilsen Marc, Schroen Blanche

Abstract excerpt

Half of all heart failure patients have preserved ejection fraction (HFpEF). Comorbidities associated with and contributing to HFpEF include obesity, diabetes and hypertension. Still, the underlying pathophysiological mechanisms of HFpEF are unknown. A preliminary consensus proposes that the multi-morbidity triggers a state of systemic, chronic low-grade inflammation, and microvascular dysfunction, causing...

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Identifiers

PMID: 29462282
DOI: 10.1093/cvr/cvy049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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