Article
Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia.
Journal of neurology - 1 Jun 2018
Jiskoot Lize C, Panman Jessica L, van Asseldonk Lauren, Franzen Sanne, Meeter Lieke H H, Donker Kaat Laura, van der Ende Emma L, Dopper Elise G P, Timman Reinier, van Minkelen Rick, van Swieten John C, van den Berg Esther, Papma Janne M
Abstract excerpt
INTRODUCTION: We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD). METHODS: Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became...
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