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Article

Unfavorable neuroblastoma prognostic factor <scp>NLRR</scp>2 inhibits cell differentiation by transcriptional induction through <scp>JNK</scp> pathway

30 Jun 2016

Abstract excerpt

The novel human gene family encoding neuronal leucine rich repeat (NLRR) proteins were identified as prognostic markers from our previous screening of primary neuroblastoma (NB) cDNA libraries. Of the NLRR gene family members, NLRR1 and NLRR3 are associated with the regulation of cellular proliferation and differentiation, respectively. However, the functional regulation and clinical significance of NLRR2 in NB...

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PMID: 27357360
DOI: 10.1111/cas.13003

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