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Article

Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes.

Familial cancer - 1 Oct 2016

Dobbins Sara E, Broderick Peter, Chubb Daniel, Kinnersley Ben, Sherborne Amy L, Houlston Richard S

Abstract excerpt

Although family history is a major risk factor for colorectal cancer (CRC) a genetic diagnosis cannot be obtained in over 50 % of familial cases when screened for known CRC cancer susceptibility genes. The genetics of undefined-familial CRC is complex and recent studies have implied additional clinically actionable mutations for CRC in susceptibility genes for other cancers. To clarify the contribution of non-CRC...

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Identifiers

PMID: 27356891
DOI: 10.1007/s10689-016-9914-4
PMCID: PMC5010824

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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