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Article

Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry.

PloS one - 1 Jan 2016

Hiraoka Kotaro, Sumiyoshi Akira, Nonaka Hiroi, Kikkawa Takako, Kawashima Ryuta, Osumi Noriko

Abstract excerpt

Pax6 is a transcription factor that pleiotropically regulates various developmental processes in the central nervous system. In a previous study, we revealed that Pax6 heterozygous mutant (rSey2/+) adult rats exhibit abnormalities in social interaction. However, the brain malformations underlying the behavioral abnormality are unknown. To elucidate the brain malformations in rSey2/+ rats, we morphometrically...

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Identifiers

PMID: 27355350
DOI: 10.1371/journal.pone.0158153
PMCID: PMC4927189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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