Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haploinsufficiency of interferon regulatory factor 6 alters brain morphology in the mouse.

American journal of medical genetics. Part A - 1 Mar 2014

Aerts Andrea, DeVolder Ian, Weinberg Seth M, Thedens Dan, Dunnwald Martine, Schutte Brian C, Nopoulos Peg

Abstract excerpt

Orofacial clefts are among the commonest birth defects. Among many genetic contributors to orofacial clefting, Interferon Regulatory Factor 6 (IRF6) is unique since mutations in this gene cause Van der Woude (VWS), the most common clefting syndrome. Furthermore, variants in IRF6 contribute to increased risk for non-syndromic cleft lip and/or palate (NSCL/P). Our previous work shows that individuals with either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cleft Lip
Share to Cleft Palate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Haploinsufficiency

Share to Interferon Regulatory Factors

Share to Magnetic Resonance Imaging

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 24357509
DOI: 10.1002/ajmg.a.36333
PMCID: PMC4100789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haploinsufficiency of interferon regulatory factor 6 alters brain morphology in the mouse.PMID 24357509Read ↗

A novel mutation in the IRF6 gene associated with facial asymmetry in a family affected with Van der Woude syndrome.Semantic proximity Read ↗

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networksSemantic proximity Read ↗

Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome.Semantic proximity Read ↗

Interferon regulatory factor 6 is required for proper wound healing in vivo.Semantic proximity Read ↗

Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development.Semantic proximity Read ↗

A heritable cause of cleft lip and palate--Van der Woude syndrome caused by a novel IRF6 mutation. Review of the literature and of the differential diagnosis.Semantic proximity Read ↗

Global and age-related neuroanatomical abnormalities in a Pax6-deficient mouse model of aniridia suggests a role for Pax6 in adult structural neuroplasticity.Semantic proximity Read ↗

Novel mutations in the IRF6 gene for Van der Woude syndrome.Semantic proximity Read ↗

Variation in IRF6 contributes to nonsyndromic cleft lip and palate.Semantic proximity Read ↗

Interferon Regulatory Factor 6 Controls Proliferation of Keratinocytes From Children With Van der Woude Syndrome.Semantic proximity Read ↗

A clinical and multi‑omics study of Van der Woude syndrome in three generations of a Chinese family.Semantic proximity Read ↗

Novel IRF6 mutations in Chinese patients with Van der Woude syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.