Article
Global and age-related neuroanatomical abnormalities in a Pax6-deficient mouse model of aniridia suggests a role for Pax6 in adult structural neuroplasticity.
Brain research - 1 Apr 2020
Grant Madison K, Bobilev Anastasia M, Rasys Ashley M, Branson Byers J, Schriever Hannah C, Hekmatyar Khan, Lauderdale James D
Abstract excerpt
PAX6 encodes a highly conserved transcription factor necessary for normal development of the eyes and central nervous system. Heterozygous loss-of-function mutations in PAX6 cause the disorder aniridia in humans and the Small eye trait in mice. Aniridia is a congenital and progressive disorder known for ocular phenotypes; however, recently, consequences of PAX6 haploinsufficiency in the brains of aniridia...
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