Article
Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria.
The Journal of cell biology - 4 Jul 2016
Miyata Non, Watanabe Yasunori, Tamura Yasushi, Endo Toshiya, Kuge Osamu
Abstract excerpt
Phosphatidylethanolamine (PE) is an essential phospholipid for mitochondrial functions and is synthesized mainly by phosphatidylserine (PS) decarboxylase at the mitochondrial inner membrane. In Saccharomyces cerevisiae, PS is synthesized in the endoplasmic reticulum (ER), such that mitochondrial PE synthesis requires PS transport from the ER to the mitochondrial inner membrane. Here, we provide evidence that...
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