Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression

29 Jun 2016

Abstract excerpt

Previous studies have demonstrated that mesenchymal stem cell (MSC) transplantation reduces the severity of collagen-induced arthritis (CIA) in mice, which is a model for rheumatoid arthritis (RA) in humans. However, the underlying molecular mechanisms remain ill-defined. Here, we showed that MSC transplantation reduced the activities of NF-κB signaling and decreased microRNA-548e (miR-548e) levels in the joint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Mesenchymal stem cell research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27354158
DOI: 10.1038/srep28915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expressionPMID 27354158Read ↗

Multi-target RNA interference: A disruptive next-generation strategy for precision treatment of rheumatoid arthritisSemantic proximity Read ↗

LIN28A‒let-7b axis drives the aggressive and proinflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytes.Semantic proximity Read ↗

BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced ArthritisSemantic proximity Read ↗

MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypesSemantic proximity Read ↗

miR-590-3p Is a Novel MicroRNA in Myocarditis by Targeting Nuclear Factor Kappa-B in vivoSemantic proximity Read ↗

Applications of RNA interference in the treatment of arthritisSemantic proximity Read ↗

MiR-379-5p aggravates experimental autoimmune uveitis in mice via the regulation of SEMA3ASemantic proximity Read ↗

Targeting NF-κB: A Promising Molecular Therapy in Inflammatory ArthritisSemantic proximity Read ↗

HDAC10 upregulation contributes to interleukin 1β‐mediated inflammatory activation of synovium‐derived mesenchymal stem cells in temporomandibular jointSemantic proximity Read ↗

The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritisSemantic proximity Read ↗

Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions.Semantic proximity Read ↗

MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.