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MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes

17 Dec 2021

Abstract excerpt

Rheumatoid arthritis (RA) is an inflammation-involved disorder and features the disruption of CD4 + T lymphocytes. Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4 + T cells. MiR-10b-deficient mice protected against collagen antibody-induced arthritis (CAIA) model. RNA sequencing results indicated that disordered genes in miR-10b −/− CAIA...

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PMID: 35317281
DOI: 10.1016/j.omtn.2021.12.022

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