Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo.

doi:10.1038/bjc.2016.198

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Article

Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo.

British journal of cancer - 26 Jul 2016

Cocco Emiliano, Lopez Salvatore, Black Jonathan, Bellone Stefania, Bonazzoli Elena, Predolini Federica, Ferrari Francesca, Schwab Carlton L, Menderes Gulden, Zammataro Luca, Buza Natalia, Hui Pei, Wong Serena, Zhao Siming, Bai Yalai, Rimm David L, Ratner Elena, Litkouhi Babak, Silasi Dan-Arin, Azodi Masoud, Schwartz Peter E, Santin Alessandro D

Abstract excerpt

BACKGROUND: Clinical options for patients harbouring advanced/recurrent uterine serous carcinoma (USC), an aggressive variant of endometrial tumour, are very limited. Next-generation sequencing (NGS) data recently demonstrated that cyclin E1 (CCNE1) gene amplification and pik3ca driver mutations are common in USC and may therefore represent ideal therapeutic targets. METHODS: Cyclin E1 expression was evaluated by...

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PMID: 27351214
DOI: 10.1038/bjc.2016.198
PMCID: PMC4973158

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CCNE1

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