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Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.

Stem cell research - 1 Jan 2016

Schröter Friederike, Sleegers Kristel, Cuyvers Elise, Bohndorf Martina, Wruck Wasco, Van Broeckhoven Christine, Adjaye James

Abstract excerpt

Human lymphoblast cells from a male patient diagnosed with Alzheimer's disease (AD) expressing the TREM2 p.R47H variant were used to generate integration-free induced pluripotent stem (iPS) cells employing episomal plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC. The iPS cells retained the TREM2 mutation, and were defined as pluripotent based on (i) expression of pluripotent-associated markers, (ii)...

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Identifiers

PMID: 27345793
DOI: 10.1016/j.scr.2015.12.017

Genes

TREM2
MYC
NANOG
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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