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Article

Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development.

Developmental biology - 15 Oct 2016

Warga Rachel M, Wicklund April, Webster Sarah E, Kane Donald A

Abstract excerpt

RacGAP1 is one of the two components of the centralspindlin complex essential for orchestrating cytokinesis in all animal cells. We report here that the early arrest mutant ogre is a maternal and zygotic loss of function mutation in the zebrafish homolog of racgap1. Like the other model organisms in which racgap1 is mutated, cells in the mutant stop dividing. In vivo cell recordings reveal that gradual loss of...

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PMID: 27339293
DOI: 10.1016/j.ydbio.2016.06.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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