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Article

Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease.

European journal of immunology - 1 Sept 2016

Raha Solaiman, Raud Brenda, Oberdörfer Linda, Castro Carla N, Schreder Alina, Freitag Jenny, Longerich Thomas, Lochner Matthias, Sparwasser Tim, Berod Luciana, Koenecke Christian, Prinz Immo

Abstract excerpt

Upon antigen-specific or allogeneic activation, T cells sharply increase their metabolic activity to cope with augmented needs for proliferation and effector functions. Therefore, enzymes involved in energy metabolism constitute attractive targets to modulate the activity of pathogenic effector T cells in the setting of graft-versus-host-disease (GVHD). Here, we show that T cells deficient for acetyl-CoA...

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Identifiers

PMID: 27338930
DOI: 10.1002/eji.201546152

Genes

TACC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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