Article
Latrophilin receptors: novel bronchodilator targets in asthma.
Thorax - 1 Jan 2017
Faiz A, Donovan C, Nieuwenhuis M Ae, van den Berge M, Postma D S, Yao S, Park C Y, Hirsch R, Fredberg J J, Tjin G, Halayko A J, Rempel K L, Ward J P T, Lee T, Bossé Y, Nickle D C, Obeidat M, Vonk Judith M, Black J L, Oliver B G, Krishnan R, McParland B, Bourke J E, Burgess J K
Abstract excerpt
BACKGROUND: Asthma affects 300 million people worldwide. In asthma, the major cause of morbidity and mortality is acute airway narrowing, due to airway smooth muscle (ASM) hypercontraction, associated with airway remodelling. However, little is known about the transcriptional differences between healthy and asthmatic ASM cells. OBJECTIVES: To investigate the transcriptional differences between asthmatic and...
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