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Article

An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia.

Oncotarget - 9 Aug 2016

Lopez Sophie, Voisset Edwige, Tisserand Julie C, Mosca Cyndie, Prebet Thomas, Santamaria David, Dubreuil Patrice, De Sepulveda Paulo

Abstract excerpt

CDK4/CDK6 and RB proteins drive the progression through the G1 phase of the cell cycle. In acute myeloid leukemia (AML), the activity of the CDK/Cyclin D complex is increased. The mechanism involved is unknown, as are the respective roles played by CDK4 or CDK6 in this process. Here, we report that AML cells carrying FLT3-ITD mutations are dependent on CDK6 for cell proliferation while CDK4 is not essential. We...

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Share to Cell Line, Tumor
Share to Cyclin-Dependent Kinase 6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred C57BL

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Source

Open in PubMed Open full text

Identifiers

PMID: 27323399
DOI: 10.18632/oncotarget.9965
PMCID: PMC5239466

Genes

CDK6
FLT3
CDK4
HCK
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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