Article
Determinants in V2C2 region of HIV-1 clade C primary envelopes conferred altered neutralization susceptibilities to IgG1b12 and PG9 monoclonal antibodies in a context-dependent manner.
Virology - 1 Aug 2014
Patil Shilpa, Choudhary Ipsita, Chaudhary Nakul K, Ringe Rajesh, Bansal Manish, Shukla Brihaspati Narayan, Boliar Saikat, Chakrabarti Bimal K, Bhattacharya Jayanta
Abstract excerpt
In the present study by examining pseudoviruses expressing patient chimeric envelopes (Envs) made between an IgG1b12 (b12)-sensitive (2-5.J3) and a b12-resistant (4.J22) HIV-1 clade C envelope, we identified determinants in the V2C2 region that governed susceptibility to b12 monoclonal antibody, but not to other CD4 binding site antibodies. Interestingly, when the V2C2 sequence of the 2-5.J3 Env was transferred...
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