Article
miRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer.
Oncotarget - 5 Jul 2016
Kim Ye Sol, Park Sae Jeong, Lee Yeon Seon, Kong Hyun Kyung, Park Jong Hoon
Abstract excerpt
Estrogen receptor-alpha (ERα) is a clinically important therapeutic target for breast cancer. However, tumors that lose ERα are less responsive to anti-estrogens such as tamoxifen. MicroRNAs (miRNAs) are small RNAs that regulate expression of their target gene and dysregulations of miRNA has been identified in many diseases including human cancer. However, only a few miRNAs associated with tamoxifen resistance...
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