Genetic risk factors for type 1 diabetes.

doi:10.1016/S0140-6736(16)30582-7

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Article

Genetic risk factors for type 1 diabetes.

Lancet (London, England) - 4 Jun 2016

Pociot Flemming, Lernmark Åke

Abstract excerpt

Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease is most likely triggered at an early age by autoantibodies primarily directed against insulin or glutamic acid decarboxylase, or both, but rarely against islet antigen-2. After the initial appearance of one of these autoantibody biomarkers, a second, third, or fourth autoantibody against either islet antigen-2 or the ZnT8...

Topics

Adolescent
Adult
Aged
Autoantibodies
Child
Child, Preschool
Diabetes Complications
Diabetes Mellitus, Type 1
Gene-Environment Interaction
Genetic Predisposition to Disease
Genome, Human
HLA Antigens
Haplotypes
Humans
Infant
Infant, Newborn
Insulin-Secreting Cells
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 27302272
DOI: 10.1016/S0140-6736(16)30582-7

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