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Article

Rho GTPases: RAC1 polymorphisms affected platinum-based chemotherapy toxicity in lung cancer patients.

Cancer chemotherapy and pharmacology - 1 Aug 2016

Zou Ting, Yin Jiye, Zheng Wei, Xiao Ling, Tan Liming, Chen Juan, Wang Ying, Li Xiangping, Qian Chenyue, Cui Jiajia, Zhang Wei, Zhou Honghao, Liu Zhaoqian

Abstract excerpt

PURPOSE: Lung cancer is the leading cause of cancer deaths in the world. The toxicity of platinum-based chemotherapy is a main reason limiting its clinical effects. RAC1, as a member of the Rho family of small guanosine triphosphatases (GTPases), was reported to be related to most cancers, such as breast cancer, gastric cancer, testicular germ cell cancer, and lung cancer. Its potential of becoming a drug target...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27299748
DOI: 10.1007/s00280-016-3072-0

Genes

RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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