Article
Mice Carrying a Ubiquitous R235W Mutation of Wnt1 Display a Bone-Specific Phenotype.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2020
Yorgan Timur Alexander, Rolvien Tim, Stürznickel Julian, Vollersen Nele, Lange Fabiola, Zhao Wenbo, Baranowsky Anke, Rosenthal Lana, Hermans-Borgmeyer Irm, Sharaf Ahmed, Karsak Meliha, David Jean-Pierre, Oheim Ralf, Amling Michael, Schinke Thorsten
Abstract excerpt
Since a key function of Wnt1 in brain development was established early on through the generation of non-viable Wnt1-deficient mice, it was initially surprising that WNT1 mutations were found to cause either early-onset osteoporosis (EOOP) or osteogenesis imperfecta type XV (OI-XV). The deduced function of Wnt1 as an osteoanabolic factor has been confirmed in various mouse models with bone-specific inactivation...
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