Article
Phase Variation in HMW1A Controls a Phenotypic Switch in Haemophilus influenzae Associated with Pathoadaptation during Persistent Infection.
mBio - 29 Jun 2021
Fernández-Calvet Ariadna, Euba Begoña, Gil-Campillo Celia, Catalan-Moreno Arancha, Moleres Javier, Martí Sara, Merlos Alexandra, Langereis Jeroen D, García-Del Portillo Francisco, Bakaletz Lauren O, Ehrlich Garth D, Porsch Eric A, Menéndez Margarita, Mell Joshua C, Toledo-Arana Alejandro, Garmendia Junkal
Abstract excerpt
Genetic variants arising from within-patient evolution shed light on bacterial adaptation during chronic infection. Contingency loci generate high levels of genetic variation in bacterial genomes, enabling adaptation to the stringent selective pressures exerted by the host. A significant gap in our understanding of phase-variable contingency loci is the extent of their contribution to natural infections. The...
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