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Article

Explaining the disease phenotype of intergenic SNP through predicted long range regulation.

Nucleic acids research - 14 Oct 2016

Chen Jingqi, Tian Weidong

Abstract excerpt

Thousands of disease-associated SNPs (daSNPs) are located in intergenic regions (IGR), making it difficult to understand their association with disease phenotypes. Recent analysis found that non-coding daSNPs were frequently located in or approximate to regulatory elements, inspiring us to try to explain the disease phenotypes of IGR daSNPs through nearby regulatory sequences. Hence, after locating the nearest...

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PMID: 27280978
DOI: 10.1093/nar/gkw519
PMCID: PMC5062962

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