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Article

β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Jun 2016

Kruger Larisa C, O'Malley Heather A, Hull Jacob M, Kleeman Amanda, Patino Gustavo A, Isom Lori L

Abstract excerpt

UNLABELLED: Voltage-gated sodium channel (VGSC) β subunits signal through multiple pathways on multiple time scales. In addition to modulating sodium and potassium currents, β subunits play nonconducting roles as cell adhesion molecules, which allow them to function in cell-cell communication, neuronal migration, neurite outgrowth, neuronal pathfinding, and axonal fasciculation. Mutations in SCN1B, encoding VGSC...

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Identifiers

PMID: 27277800
DOI: 10.1523/JNEUROSCI.0405-16.2016
PMCID: PMC4899524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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