Article
Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2016
Zhu Wei, Gramlich Oliver W, Laboissonniere Lauren, Jain Ankur, Sheffield Val C, Trimarchi Jeffrey M, Tucker Budd A, Kuehn Markus H
Abstract excerpt
Glaucoma is a common cause of vision loss or blindness and reduction of intraocular pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP is maintained by the trabecular meshwork (TM) and the elevation of IOP in open-angle glaucoma is associated with dysfunction and loss of the postmitotic cells residing within this tissue. To determine if IOP control can be maintained by...
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