Article

Dual SMAD inhibition and Wnt inhibition enable efficient and reproducible differentiations of induced pluripotent stem cells into retinal ganglion cells

2019-07-01

Abstract excerpt

Glaucoma is a group of progressive optic neuropathies that share common biological and clinical characteristics including irreversible changes to the optic nerve and visual field loss caused by death of retinal ganglion cells (RGCs). The loss of RGCs manifests as characteristic cupping or optic nerve degeneration, resulting in visual field loss in patients with Glaucoma. Published studies on in vitro RGC differen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7bc0f37b-4e3f-55b4-982a-75944824e6c5
DOI: 10.1101/682666

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dual SMAD inhibition and Wnt inhibition enable efficient and reproducible differentiations of induced pluripotent stem cells into retinal ganglion cellsDOI 10.1101/682666Read

Dual SMAD inhibition and Wnt inhibition enable efficient and reproducible differentiations of induced pluripotent stem cells into retinal ganglion cellsSemantic proximity Read

Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental MechanismSemantic proximity Read

Glaucoma, Stem Cells, and Gene Therapy: Where Are We Now?Semantic proximity Read

Preservation of vision after chemically induced retinal ganglion-like-cell transplantationSemantic proximity Read

Cell transplantation of retinal ganglion cells derived from hESCsSemantic proximity Read

Directed robust generation of functional retinal ganglion cells from Müller gliaSemantic proximity Read

Isolation and Molecular Profiling of Primary Mouse Retinal Ganglion Cells: Comparison of Phenotypes from Healthy and Glaucomatous RetinasSemantic proximity Read

Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineeringSemantic proximity Read

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step ImmunopanningSemantic proximity Read

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration.Semantic proximity Read

The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathiesSemantic proximity Read

Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases.Semantic proximity Read