Article
Viral Decay Dynamics and Mathematical Modeling of Treatment Response: Evidence of Lower in vivo Fitness of HIV-1 Subtype C.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2016
Shet Anita, Nagaraja Pradeep, Dixit Narendra M
Abstract excerpt
BACKGROUND: Despite the high prevalence of HIV-1 subtype C (HIV-1C) worldwide, information on HIV-1C viral dynamics and response to antiretroviral therapy (ART) is limited. We sought to measure viral load decay dynamics during treatment and estimate the within-host basic reproductive ratio, R0, and the critical efficacy, εc, for successful treatment of HIV-1C infection. METHODS: Individuals initiated on...
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