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Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

3 Jun 2016

Abstract excerpt

The notion of utilizing cell-free DNA (cfDNA)8 in the circulation as a surrogate biomarker is not a novel concept. Mandel and Metais identified the presence of cfDNA in the blood of healthy individuals almost 60 years ago. Decades later, multiple groups were able to extend the work of Mandel and Metais into the identification of tumor-derived cfDNA—also known as circulating tumor DNA (ctDNA)—in the blood of...

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PMID: 27259816
DOI: 10.1373/clinchem.2016.260331

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