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Detection and Diagnostic Utilization of Cellular and Cell-Free Tumor DNA

24 Nov 2020

Abstract excerpt

Because cancer is caused by an accumulation of genetic mutations, mutant DNA released by tumors can be used as a highly specific biomarker for cancer. Although this principle was described decades ago, the advent and falling costs of next-generation sequencing have made the use of tumor DNA as a biomarker increasingly practical. This review surveys the use of cellular and cell-free DNA for the detection of...

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PMID: 33228464
DOI: 10.1146/annurev-pathmechdis-012419-032604

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