Quantification of the relative contribution of environmental and genetic factors to variation in cystic fibrosis lung function.

doi:10.1016/j.jpeds.2010.05.018

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Article

Quantification of the relative contribution of environmental and genetic factors to variation in cystic fibrosis lung function.

The Journal of pediatrics - 1 Nov 2010

Collaco J Michael, Blackman Scott M, McGready John, Naughton Kathleen M, Cutting Garry R

Abstract excerpt

OBJECTIVE: To assess the relative contributions of environmental and genetic factors to variation in cystic fibrosis (CF) lung disease. STUDY DESIGN: Genetic and environmental contributions were quantified by use of intrapair correlations and differences in CF-specific forced expiratory volume in 1 second measures from 134 monozygous twins and 272 dizygous twins and siblings while in different living environments...

Topics

Adolescent
Adult
Child
Cystic Fibrosis
Environment
Female
Genetic Predisposition to Disease
Humans
Lung
Male
Young Adult

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Identifiers

PMID: 20580019
DOI: 10.1016/j.jpeds.2010.05.018
PMCID: PMC2948620

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