Article
Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos.
American journal of human genetics - 7 Jan 2016
Conomos Matthew P, Laurie Cecelia A, Stilp Adrienne M, Gogarten Stephanie M, McHugh Caitlin P, Nelson Sarah C, Sofer Tamar, Fernández-Rhodes Lindsay, Justice Anne E, Graff Mariaelisa, Young Kristin L, Seyerle Amanda A, Avery Christy L, Taylor Kent D, Rotter Jerome I, Talavera Gregory A, Daviglus Martha L, Wassertheil-Smoller Sylvia, Schneiderman Neil, Heiss Gerardo, Kaplan Robert C, Franceschini Nora, Reiner Alex P, Shaffer John R, Barr R Graham, Kerr Kathleen F, Browning Sharon R, Browning Brian L, Weir Bruce S, Avilés-Santa M Larissa, Papanicolaou George J, Lumley Thomas, Szpiro Adam A, North Kari E, Rice Ken, Thornton Timothy A, Laurie Cathy C
Abstract excerpt
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental exposures. Here, we characterized and controlled for this diversity in genome-wide association studies (GWASs) for the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We simultaneously estimated population-structure principal components (PCs) robust to familial relatedness and pairwise kinship coefficients...
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