Article
Genomic correlation, shared loci, and causal association between obesity, periodontitis and tooth loss.
Scientific reports - 12 Feb 2025
Chen Lin, Qu Yang, Cui Huijie, Zhang Wenqiang, Wu Xuan, Zhao Xunying, Xiao Jinyu, Tang Mingshuang, Wang Yutong, Zou Yanqiu, Qiu Lingli, Tan Zhixin, Lei Bowen, Ma Xiaofeng, Zhang Di, Liu Yunjie, Fan Mengyu, Li Jiayuan, Zhang Ben, Jiang Xia
Abstract excerpt
Observational studies have reported an association of obesity with periodontitis and tooth loss, yet findings remain inconsistent. We aim to investigate the genetic link underlying obesity-related traits (BMI [body mass index], WHR [waist-to-hip ratio], WHRadjBMI and childhood BMI), periodontitis and tooth loss. Leveraging summary statistics from large-scale genome-wide association studies, we comprehensively...
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